Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.55 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359102 | 1.00 | TLR8 (0.57) | TLR8ALDH1A1KDM4EGAAHPGD | |
| Hydrochloric Acid SCHEMBL27365120 | 0.98 | TLR8 (0.55) | TLR8ALDH1A1KDM4EGAAHPGD | |
| Urea SCHEMBL21829040 | 0.90 | IKBKB (0.66) | TLR8ALDH1A1KDM4EGAAHPGD | |
| Acridine SCHEMBL10827474 | 0.78 | ALDH1A1 (0.75) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL1133368 | 0.77 | ALDH1A1 (0.52) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL5745605 | 0.77 | TDP1 (0.59) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3300463 | 0.77 | TLR8 (0.53) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL358560 | 0.77 | TDP1 (0.59) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL8788171 | 0.77 | ALDH1A1 (0.52) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL949288 | 0.77 | ALDH1A1 (0.59) | TLR8ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976039-A4 | BISAMINOQUINOLINES AND BISAMINOACRIDINES COMPOUNDS AND METHODS OF THEIR USE | The Trustees of The University of Pennsylvania (US) | 2023-06-07 | — | — | EP | disclosed |
| EP-3976039-A1 | BISAMINOQUINOLINES AND BISAMINOACRIDINES COMPOUNDS AND METHODS OF THEIR USE | The Trustees of The University of Pennsylvania (US) | 2022-04-06 | — | — | EP | disclosed |