Sugi Predict

Sugi Predict / Compounds / SCHEMBL3300463

SCHEMBL3300463

SCHEMBL3300463

Nc1nc2ccccc2cc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TLR8 Q9NR97 7/20 0.53
▸ ALDH1A1 P00352 5/20 0.53
▸ KDM4E B2RXH2 4/20 0.53
▸ GAA P10253 3/20 0.53
▸ HPGD P15428 3/20 0.52
▸ MAPT P10636 2/20 0.52
▸ GLA P06280 2/20 0.52
▸ ACHE P22303 1/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ IKBKB O14920 1/20 0.52
▸ NPC1 O15118 3/20 0.49
▸ RAB9A P51151 3/20 0.49
▸ KMT2A Q03164 3/20 0.49
▸ MEN1 O00255 1/20 0.49
▸ HTR3A P46098 1/20 0.48
▸ ATM Q13315 1/20 0.47
▸ LMNA P02545 1/20 0.47
▸ POLB P06746 1/20 0.47
▸ PTBP1 P26599 1/20 0.47
▸ RCE1 Q9Y256 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29911350 1.00 TLR8 (0.53) TLR8ALDH1A1KDM4EGAAHPGD
SCHEMBL359102 0.77 TLR8 (0.57) TLR8ALDH1A1KDM4EGAAHPGD
SCHEMBL29911341 0.77 KMT2A (0.59) ALDH1A1KDM4EGAAHPGDMAPT
SCHEMBL244868 0.77 KMT2A (0.59) ALDH1A1KDM4EGAAHPGDMAPT
SCHEMBL29454362 0.77 TLR8 (0.57) TLR8ALDH1A1KDM4EGAAHPGD
SCHEMBL31278632 0.76 KMT2A (0.57) ALDH1A1KDM4EGAAHPGDMAPT
Hydrochloric Acid SCHEMBL27365120 0.76 TLR8 (0.55) TLR8ALDH1A1KDM4EGAAHPGD
SCHEMBL846680 0.74 KMT2A (0.55) TLR8ALDH1A1KDM4EGAAHPGD
SCHEMBL538069 0.74 ALDH1A1 (0.52) ALDH1A1KDM4EGAAHPGDMAPT
SCHEMBL1467074 0.74 ALDH1A1 (0.59) ALDH1A1KDM4EGAAHPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003013523-A1 SH3 PROTEIN DOMAINS AND THEIR LIGANDS ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) 2003-02-20 — — WO claimed
US-11952380-B2 Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors LUPIN LIMITED (IN) 2024-04-09 — — US disclosed
CN-117157297-A PRMT5 inhibitors 上海齐鲁制药研究中心有限公司 2023-12-01 — — CN disclosed
US-20230322803-A1 SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER BRISTOL MYERS SQUIBB CO (US) 2023-10-12 — — US disclosed
WO-2023001133-A1 PRMT5 INHIBITOR 上海齐鲁制药研究中心有限公司 2023-01-26 — — WO disclosed
US-20220112194-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. 2022-04-14 — — US disclosed
US-11198699-B2 Compounds targeting PRMT5 ALIGOS THERAPEUTICS, INC. (US) 2021-12-14 — — US disclosed
EP-3911642-A1 NLRP3 MODULATORS Innate Tumor Immunity, Inc. (US) 2021-11-24 — — EP disclosed
WO-2020205867-A1 COMPOUNDS TARGETING PRMT5 ALIGOS THERAPEUTICS, INC. (US) 2020-10-08 — — WO disclosed
WO-2020150116-A1 NLRP3 MODULATORS INNATE TUMOR IMMUNITY, INC. (US) 2020-07-23 — — WO disclosed
CN-101296909-B pyrazine derivatives and application thereof as PI3K inhibitor SERONO LAB 2011-10-12 — — CN disclosed
US-20100266539-A1 CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2010-10-21 — — US disclosed
US-7732442-B2 Chemokine receptor antagonist and medical use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2010-06-08 — — US disclosed
CN-101296909-A Pyrazine derivatives and application thereof as PI3K inhibitor SERONO LAB (CH) 2008-10-29 — — CN disclosed
US-20070254886-A1 Chemokine Receptor Antagonist and Medical Use Thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2007-11-01 — — US disclosed
EP-1661889-A1 CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2006-05-31 — — EP disclosed
CN-1678586-A Substituted quinoline CCR5 receptor antagonists SCHERING AG (DE) 2005-10-05 — — CN disclosed
EP-1385833-A1 TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS Amgen Inc. (US) 2004-02-04 — — EP disclosed
WO-2003013523-A1 SH3 PROTEIN DOMAINS AND THEIR LIGANDS ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) 2003-02-20 — — WO disclosed
WO-2002083654-A1 TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS AMGEN INC. (US) 2002-10-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230322803-A1 SUBSTITUTED OXOISOINDOLINE COMPOUNDS FOR THE TREATMENT OF CANCER DDX21, HRAS, RPL17 TLR8 4627/4885ALDH1A1 1946/4885KDM4E 2305/4885
US-11198699-B2 Compounds targeting PRMT5 PRMT5, PRMT1, PRMT6 TLR8 4159/4885ALDH1A1 3913/4885KDM4E 47/4885
US-20220112194-A1 COMPOUNDS TARGETING PRMT5 PRMT5, PRMT1, PRMT6 TLR8 4159/4885ALDH1A1 3913/4885KDM4E 47/4885
US-11952380-B2 Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors PRMT5, PRMT1, PRMT3 TLR8 4654/4885ALDH1A1 2553/4885KDM4E 47/4885
US-20100266539-A1 CHEMOKINE RECEPTOR ANTAGONIST AND MEDICAL USE THEREOF CCR5, CCR4, CCR1 TLR8 161/4885ALDH1A1 2497/4885KDM4E 4430/4885
US-20070254886-A1 Chemokine Receptor Antagonist and Medical Use Thereof CCR5, CCR4, CCR1 TLR8 161/4885ALDH1A1 2497/4885KDM4E 4430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.