Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.55 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29454362 | 1.00 | TLR8 (0.57) | TLR8ALDH1A1KDM4EGAAHPGD | |
| Hydrochloric Acid SCHEMBL27365120 | 0.98 | TLR8 (0.55) | TLR8ALDH1A1KDM4EGAAHPGD | |
| Urea SCHEMBL21829040 | 0.90 | IKBKB (0.66) | TLR8ALDH1A1KDM4EGAAHPGD | |
| Acridine SCHEMBL10827474 | 0.78 | ALDH1A1 (0.75) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL1133368 | 0.77 | ALDH1A1 (0.52) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL5745605 | 0.77 | TDP1 (0.59) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3300463 | 0.77 | TLR8 (0.53) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL358560 | 0.77 | TDP1 (0.59) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL8788171 | 0.77 | ALDH1A1 (0.52) | TLR8ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL949288 | 0.77 | ALDH1A1 (0.59) | TLR8ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114058422-B | Mannich ashless dispersant and preparation method thereof | 中国石油天然气股份有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-113004775-B | Nano-carbon doped shaped phase change energy storage coating and preparation method thereof | 辽宁大学 | 2022-07-19 | — | — | CN | claimed |
| CN-114057916-A | Preparation method of antioxidant ashless dispersant for lubricating oil | 中国石油天然气股份有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-114058422-A | Mannich ashless dispersant and preparation method thereof | 中国石油天然气股份有限公司 | 2022-02-18 | — | — | CN | claimed |
| CN-112608336-B | Quinoline diamine-containing fourth subgroup metal complex and application thereof | 吉林大学 | 2021-12-28 | — | — | CN | claimed |
| CN-111187207-B | Bisamidoquinoline probe molecule and preparation method and application thereof | 齐齐哈尔大学 | 2021-06-29 | — | — | CN | claimed |
| CN-113004775-A | Nano-carbon doped shaped phase change energy storage coating and preparation method thereof | 辽宁大学 | 2021-06-22 | — | — | CN | claimed |
| CN-112608336-A | Quinoline diamine-containing fourth subgroup metal complex and application thereof | 吉林大学 | 2021-04-06 | — | — | CN | claimed |
| CN-111187207-A | Bisamidoquinoline probe molecule and preparation method and application thereof | 齐齐哈尔大学 | 2020-05-22 | — | — | CN | claimed |
| US-20190247397-A1 | COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION | THE JOHNS HOPKINS UNIVERSITY | 2019-08-15 | — | — | US | claimed |
| EP-3515448-A1 | COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION | The Johns Hopkins University (US) | 2019-07-31 | — | — | EP | claimed |
| WO-2018057834-A1 | COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-03-29 | — | — | WO | claimed |
| EP-1413286-B1 | Dyeing composition comprising at least one heterocyclic oxidation base and at least one substituted 2,3-diaminopyridine as a coupling agent | OREAL (FR) | 2009-04-22 | — | — | EP | claimed |
| EP-1085086-B1 | Method for producing L-histidine by fermentation using DNA gyrase inhibitor resistant bacterial strains | KYOWA HAKKO KOGYO KK (JP) | 2008-03-19 | — | — | EP | claimed |
| WO-2007071688-A1 | COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER | L'ORÉAL (FR) | 2007-06-28 | — | — | WO | claimed |
| CN-1057546-C | Reinforced rubber article, production thereof and rubber composition suitable therefor | SUMITOMO CHEMICAL CO (JP) | 2000-10-18 | — | — | CN | claimed |
| CN-1035057-C | Method of preventing polymer scale formation | SHINETSU CHEMICAL CO (JP) | 1997-06-04 | — | — | CN | claimed |
| EP-0473094-B1 | Process for producing L-tryptophan | KYOWA HAKKO KOGYO KK (JP) | 1995-06-21 | — | — | EP | claimed |
| CN-1093724-A | Reinforcing rubber articles, its production method and suitable rubber combination | SUMITOMO CHEMICAL CO (JP) | 1994-10-19 | — | — | CN | claimed |
| CN-1040206-A | Prevent to form the method for polymer scale formation | SHINETSU CHEMICAL CO (JP) | 1990-03-07 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190247397-A1 | COMBINATORY TREATMENT STRATEGIES OF CANCER BASED ON RNA POLYMERASE I INHIBITION | ACAT1, PARP1, POLRMT | TLR8 4534/4885ALDH1A1 935/4885KDM4E 2864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.