SCHEMBL29454524

SCHEMBL29454524

Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 11/20 1.00
▸ KDM4E B2RXH2 1/20 0.98
▸ MEN1 O00255 1/20 0.98
▸ ALDH1A1 P00352 1/20 0.98
▸ MAPT P10636 1/20 0.98
▸ HPGD P15428 1/20 0.98
▸ ALOX15 P16050 1/20 0.98
▸ TSHR P16473 1/20 0.98
▸ CASP1 P29466 1/20 0.98
▸ BLM P54132 1/20 0.98
▸ CASP7 P55210 1/20 0.98
▸ KMT2A Q03164 1/20 0.98
▸ SMN1; SMN2 Q16637 1/20 0.98
▸ HSD17B10 Q99714 1/20 0.98
▸ TDP1 Q9NUW8 1/20 0.98

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433473 1.00 ADK (1.00) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL1914142 1.00 ADK (1.00) ADKKDM4EMEN1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL29941043 0.99 ADK (1.00) ADKKDM4EMEN1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL29940884 0.99 ADK (1.00) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL2036328 0.91 ADK (1.00) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL2035229 0.91 ADK (0.84) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8267958 0.91 ADK (0.83) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8193961 0.90 ADK (0.98) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL2037666 0.90 ADK (0.82) ADKKDM4EMEN1ALDH1A1MAPT
SCHEMBL8258006 0.90 ADK (0.81) ADKKDM4EMEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260024617-A1 METHODS AND SYSTEMS FOR PERSONALIZED THERAPIES SCIPHER MEDICINE CORP (US) 2026-01-22 — — US disclosed
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 — — EP disclosed
US-20250346631-A1 PEPTIDE COMPOSITIONS AND METHODS OF USE ONL THERAPEUTICS INC (US) 2025-11-13 — — US disclosed
EP-4623925-A2 PEPTIDE COMPOSITIONS AND METHODS OF USE ONL Therapeutics, Inc. (US) 2025-10-01 — — EP disclosed
US-20250186593-A1 TARGETED DELIVERY TO BETA CELLS THE BROAD INSTITUTE, INC. 2025-06-12 — — US disclosed
US-20250136990-A1 ANTISENSE OLIGONUCLEOTIDES TARGETING ADENOSINE KINASE NEUMIRNA THERAPEUTICS APS (DK) 2025-05-01 — — US disclosed
US-12258425-B2 Peptide compositions and methods of use ONL THERAPEUTICS, INC. 2025-03-25 — — US disclosed
US-12208140-B2 Targeted delivery to beta cells THE BROAD INSTITUTE, INC. (US) 2025-01-28 — — US disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 — — WO disclosed
US-20240240188-A1 ANTISENSE OLIGONUCLEOTIDES TARGETING ADENOSINE KINASE NEUMIRNA THERAPEUTICS APS (DK) 2024-07-18 — — US disclosed
US-20220323468-A1 REDUCED NICOTINAMIDERIBOSIDES FOR THE TREATMENT/PREVENTION OF LIVER DISEASE UNIVERSITY OF SOUTH ALABAMA 2022-10-13 — — US disclosed
US-20220296623-A1 REDUCED NICOTINAMIDERIBOSIDES FOR TREATING OR PREVENTING KIDNEY DISEASE UNIVERSITY OF SOUTH ALABAMA 2022-09-22 — — US disclosed
WO-2022187437-A1 COMPOSITIONS AND METHODS FOR MONITORING ENPP1 ACTIVITY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-09-09 — — WO disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 — — US disclosed
US-20220233565-A1 REDUCED NICOTINAMIDERIBOSIDES FOR TREATING/PREVENTING SKELETAL MUSCLE DISEASE NESTLE SA (CH) 2022-07-28 — — US disclosed
EP-3997981-A1 PEPTIDE COMPOSITIONS AND METHODS OF USE Onl Therapeutics, Inc. (US) 2022-05-18 — — EP disclosed
EP-3980027-A1 REDUCED NICOTINAMIDERIBOSIDES FOR THE TREATMENT/PREVENTION OF LIVER DISEASE Société des Produits Nestlé S.A. (CH) 2022-04-13 — — EP disclosed
EP-3980028-A1 REDUCED NICOTINAMIDERIBOSIDES FOR TREATING/PREVENTING SKELETAL MUSCLE DISEASE Société des Produits Nestlé S.A. (CH) 2022-04-13 — — EP disclosed
EP-3980026-A1 REDUCED NICOTINAMIDERIBOSIDES FOR TREATING OR PREVENTING KIDNEY DISEASE Société des Produits Nestlé S.A. (CH) 2022-04-13 — — EP disclosed
US-20220087987-A1 A METHOD FOR TREATING SWI/SNF COMPLEX-DEFICIENT CANCERS COMPRISING GLUTATHIONE (GSH) METABOLIC PATHWAY INHIBITOR NATIONAL CANCER CENTER (JP) 2022-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250346631-A1 PEPTIDE COMPOSITIONS AND METHODS OF USE VIP, TNFSF10, IAPP ADK 4022/4885KDM4E 4831/4885MEN1 3692/4885
US-20220296623-A1 REDUCED NICOTINAMIDERIBOSIDES FOR TREATING OR PREVENTING KIDNEY DISEASE NNT, NADK, NAMPT ADK 199/4885KDM4E 1206/4885MEN1 2739/4885
US-20220233565-A1 REDUCED NICOTINAMIDERIBOSIDES FOR TREATING/PREVENTING SKELETAL MUSCLE DISEASE SIRT1, NAMPT, NNT ADK 977/4885KDM4E 925/4885MEN1 3677/4885
US-20260024617-A1 METHODS AND SYSTEMS FOR PERSONALIZED THERAPIES SET, SSB, CNKSR1 ADK 4629/4885KDM4E 1927/4885MEN1 3789/4885
US-12208140-B2 Targeted delivery to beta cells IAPP, ZFR, ZC3H11A ADK 2148/4885KDM4E 1462/4885MEN1 2406/4885
US-20250186593-A1 TARGETED DELIVERY TO BETA CELLS IAPP, ZFR, ZC3H11A ADK 2148/4885KDM4E 1462/4885MEN1 2406/4885
US-12258425-B2 Peptide compositions and methods of use VIP, TNFSF10, IAPP ADK 4143/4885KDM4E 4836/4885MEN1 3610/4885
US-20220323468-A1 REDUCED NICOTINAMIDERIBOSIDES FOR THE TREATMENT/PREVENTION OF LIVER DISEASE NNT, NAMPT, NNMT ADK 553/4885KDM4E 1230/4885MEN1 4316/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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