SCHEMBL294606

SCHEMBL294606

CC1(C)C(CC(Cl)(Cl)Cl)C1C(=O)OCc1cccc(Oc2ccccc2)c1

nearest known ligand 0.67

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.67
LMNA P02545 1/20 0.67
ADRA2A P08913 1/20 0.67
CNR1 P21554 1/20 0.67
ATM Q13315 1/20 0.67
L3MBTL1 Q9Y468 1/20 0.67
FKBP1A P62942 3/20 0.48
MMP1 P03956 2/20 0.47
MMP2 P08253 1/20 0.47
MMP9 P14780 1/20 0.47
MMP12 P39900 1/20 0.47
CETP P11597 1/20 0.44
FFAR1 O14842 6/20 0.41
FFAR4 Q5NUL3 2/20 0.41
CCR8 P51685 1/20 0.41
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
PTGES O14684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10972736 0.94 TDP1 (0.64) TDP1LMNAADRA2ACNR1ATM
SCHEMBL10976834 0.94 TDP1 (0.64) TDP1LMNAADRA2ACNR1ATM
SCHEMBL10973029 0.93 TDP1 (0.58) TDP1LMNAADRA2ACNR1ATM
SCHEMBL10975825 0.92 TDP1 (0.57) TDP1LMNAADRA2ACNR1ATM
SCHEMBL10971890 0.91 TDP1 (0.64) TDP1LMNAADRA2ACNR1ATM
SCHEMBL10971457 0.91 TDP1 (0.64) TDP1LMNAADRA2ACNR1ATM
SCHEMBL5327652 0.90 TDP1 (0.60) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11237046 0.88 TDP1 (0.60) TDP1LMNAADRA2ACNR1ATM
SCHEMBL2127178 0.87 TDP1 (0.67) TDP1LMNAADRA2ACNR1ATM
SCHEMBL21820776 0.86 TDP1 (0.74) TDP1LMNAADRA2ACNR1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4390547-A 2,2-Dimethyl-3-(substituted ethyl)cyclopropane carboxylate pesticidal compositions and methods KURARAY CO., LTD. (JP) 1983-06-28 US claimed
JP-54059261-A None JP disclosed
JP-55083703-A None JP disclosed
JP-55083704-A None JP disclosed
EP-1683782-B1 Chiral copper complex and production processes thereof and using the same SUMITOMO CHEMICAL CO (JP) 2012-03-14 EP disclosed
EP-1120402-B1 Chiral copper complex and production processes thereof and using the same SUMITOMO CHEMICAL CO (JP) 2008-06-25 EP disclosed
EP-1683783-A2 Chiral copper complex and production processes thereof and using the same Sumitomo Chemical Company, Limited (JP) 2006-07-26 EP disclosed
EP-1683782-A2 Chiral copper complex and production processes thereof and using the same Sumitomo Chemical Company, Limited (JP) 2006-07-26 EP disclosed
US-20050090684-A1 Chiral copper complex and production processes thereof and using the same SUMITOMO CHEMICAL CO., LTD. 2005-04-28 US disclosed
US-6670500-B2 Chiral copper complex and production processes thereof and using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-12-30 US disclosed
US-20020004618-A1 Chiral copper complex and production processes thereof and using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-01-10 US disclosed
EP-1120402-A2 Chiral copper complex and production processes thereof and using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-08-01 EP disclosed
US-4532258-A Controlling insects, mites, pests KURARAY CO., LTD. (JP) 1985-07-30 US disclosed
US-4390547-A 2,2-Dimethyl-3-(substituted ethyl)cyclopropane carboxylate pesticidal compositions and methods KURARAY CO., LTD. (JP) 1983-06-28 US disclosed
US-4299839-A Novel pesticides and pesticidal compositions cyclopropanecarboxylates and pesticidal method KURARAY CO., LTD. (JP) 1981-11-10 US disclosed
JP-S5583704-A INSECTICIDE KURARAY CO LTD 1980-06-24 JP disclosed
JP-S5583703-A MIXED INSECTICIDE KURARAY CO LTD 1980-06-24 JP disclosed
JP-S5459261-A SUBSTITUTED CYCLOPROPANECARBOXYLIC ACID DERIVATIVE KURARAY CO LTD 1979-05-12 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050090684-A1 Chiral copper complex and production processes thereof and using the same SOD1, CYP1A1, NFXL1 TDP1 4523/4885LMNA 4567/4885ADRA2A 1258/4885
US-20020004618-A1 Chiral copper complex and production processes thereof and using the same SOD1, XDH, NFXL1 TDP1 3929/4885LMNA 4559/4885ADRA2A 2256/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.