Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22538607 | 1.00 | ADRA1A (0.41) | ADRA1ANPEPPSGAAMEN1KMT2A | |
| SCHEMBL17443847 | 1.00 | ADRA1A (0.41) | ADRA1ANPEPPSGAAMEN1KMT2A | |
| SCHEMBL4356963 | 0.84 | ALDH1A1 (0.45) | ADRA1AMEN1KMT2AALDH1A1HTT | |
| SCHEMBL3406286 | 0.80 | ALDH1A1 (0.42) | NPEPPSGAAKDM4ECASP1HSD17B10 | |
| SCHEMBL25001783 | 0.80 | ALDH1A1 (0.35) | NPEPPSGAAMEN1KMT2AKDM4E | |
| SCHEMBL4253610 | 0.79 | PKM (0.41) | GAAMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL4830643 | 0.77 | ADORA2B (0.39) | GAAMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL3934689 | 0.76 | PKM (0.39) | GAAMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL3931328 | 0.75 | KDM4E (0.34) | GAAMEN1KMT2AKDM4EHSD17B10 | |
| SCHEMBL3970345 | 0.74 | PSEN1 (0.35) | CASP1HSD17B10CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081666-A1 | COMPOUNDS AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-108602777-B | 3- ((hetero-) aryl) -alkyl-8-amino-2-oxo-1, 3-aza-spiro- [4.5] -decane derivative | 格吕伦塔尔有限公司 | 2022-05-03 | — | — | CN | disclosed |
| CN-114149413-A | 3- ((hetero) aryl) -8-amino-2-oxo-1, 3-aza-spiro- [4.5] -decane derivatives | 格吕伦塔尔有限公司 | 2022-03-08 | — | — | CN | disclosed |