Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proxyfan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proxyfan SCHEMBL15929504 | 0.93 | HRH3 (1.00) | HRH3HRH4 | |
| SCHEMBL4217229 | 0.76 | HRH3 (0.58) | HRH3HRH4 | |
| SCHEMBL18536735 | 0.76 | HRH3 (0.57) | HRH3HRH4 | |
| SCHEMBL2536900 | 0.75 | HRH3 (0.93) | HRH3HRH4 | |
| Proxyfan SCHEMBL15130144 | 0.74 | HRH3 (0.48) | HRH3HRH4 | |
| SCHEMBL224745 | 0.71 | TAAR1 (1.00) | HRH3HRH4 | |
| SCHEMBL6816189 | 0.70 | LTA4H (0.58) | HRH3HRH4 | |
| SCHEMBL194703 | 0.70 | HRH3 (0.71) | HRH3HRH4 | |
| SCHEMBL4069939 | 0.69 | TDP1 (0.64) | HRH3HRH4 | |
| SCHEMBL13851684 | 0.69 | TBXAS1 (0.84) | HRH3HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943564-B1 | SL327 FOR USE IN SKIN REGENERATION | INT STEM CELL CORPORATION (US) | 2026-03-25 | — | — | EP | disclosed |
| US-20230035892-A1 | METHODS AND COMPOSITIONS FOR TREATING CANCER | FLAGSHIP PIONEERING, INC. | 2023-02-02 | — | — | US | disclosed |
| US-11383084-B2 | Treatment of dermatological conditions via neuromodulation | PALO ALTO INVESTORS (US) | 2022-07-12 | — | — | US | disclosed |
| US-11274158-B2 | Methods and compositions for treating inflammatory or autoimmune diseases or conditions using calcitonin receptor activators | FLAGSHIP PIONEERING INNOVATIONS V, INC. (US) | 2022-03-15 | — | — | US | disclosed |