Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582642 | 0.91 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL7649455 | 0.89 | PTPN1 (0.47) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL5219494 | 0.89 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL14188965 | 0.86 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL5220816 | 0.85 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL3823448 | 0.85 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL5224397 | 0.84 | TAAR1 (0.54) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL3574940 | 0.84 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL3576116 | 0.84 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL28712089 | 0.83 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118076-B1 | QUINOXALINE COMPOUNDS AND USE THEREOF | MERCK SERONO SA (CH) | 2019-09-04 | — | — | EP | disclosed |
| EP-2118076-B1 | QUINOXALINE COMPOUNDS AND USE THEREOF | MERCK SERONO SA (CH) | 2019-09-04 | — | — | EP | disclosed |
| US-8614215-B2 | Quinoxaline inhibitors of phosphoinositide-3-kinases (PI3Ks) | MERCK SERONO SA (CH) | 2013-12-24 | — | — | US | disclosed |
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | MERCK SERONO SA (CH) | 2010-06-03 | — | — | US | disclosed |
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | MERCK SERONO SA (CH) | 2010-06-03 | — | — | US | disclosed |
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | MERCK SERONO SA (CH) | 2010-06-03 | — | — | US | disclosed |
| EP-1765267-B1 | INITIAL PHENYLPROPANEDIOL DYE PRODUCTS | HENKEL AG & CO KGAA (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-1754685-B1 | Organosol of silica and process for producing the same | NISSAN CHEMICAL IND LTD (JP) | 2010-01-06 | — | — | EP | disclosed |
| EP-1765267-B1 | INITIAL PHENYLPROPANEDIOL DYE PRODUCTS | HENKEL AG & CO KGAA (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2118076-A1 | QUINOXALINE COMPOUNDS AND USE THEREOF | Merck Serono S.A. (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-7560491-B2 | Z-stilbenes derivatives and the pharmaceutical composition thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2009-07-14 | — | — | US | disclosed |
| WO-2008101979-A1 | QUINOXALINE COMPOUNDS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2008-08-28 | — | — | WO | disclosed |
| WO-2008101979-A1 | QUINOXALINE COMPOUNDS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2008-08-28 | — | — | WO | disclosed |
| US-20080096973-A1 | Z-stilbenes derivatives and the pharmaceutical composition thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2008-04-24 | — | — | US | disclosed |
| EP-1765267-A1 | INITIAL PHENYLPROPANEDIOL DYE PRODUCTS | Henkel Kommanditgesellschaft auf Aktien (DE) | 2007-03-28 | — | — | EP | disclosed |
| EP-1754685-A2 | Organosol of silica and process for producing the same | Nissan Chemical Industries, Ltd. (JP) | 2007-02-21 | — | — | EP | disclosed |
| US-20070032560-A1 | Organosol of silica and process for producing same | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| WO-2006002712-A1 | INITIAL PHENYLPROPANEDIOL DYE PRODUCTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137308-A1 | Quinoxaline Compounds and Use Thereof | PFKP, PDXK, PF4 | ALDH1A1 577/4885SMN1; SMN2 3366/4885NPC1 4792/4885 |
| US-20080096973-A1 | Z-stilbenes derivatives and the pharmaceutical composition thereof | CCNB1, ZYX, H1-0 | ALDH1A1 924/4885SMN1; SMN2 2954/4885NPC1 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.