Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | SCN1A | P35498 | 4/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.35 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EIF2AK3 | Q9NZJ5 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19928762 | 1.00 | HSD11B1 (0.38) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL19925090 | 0.90 | SCN1A (0.37) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL29464325 | 0.90 | SCN1A (0.37) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL29464481 | 0.86 | HSD11B1 (0.36) | HSD11B1L3MBTL1SCN9A | |
| SCHEMBL19968772 | 0.86 | HSD11B1 (0.36) | HSD11B1L3MBTL1SCN9A | |
| SCHEMBL19925087 | 0.86 | HSD11B1 (0.35) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL29464313 | 0.86 | HSD11B1 (0.35) | HSD11B1SCN1ASCN5ASCN8AL3MBTL1 | |
| SCHEMBL29464474 | 0.86 | HSD11B1 (0.36) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL19925085 | 0.86 | HSD11B1 (0.36) | HSD11B1SCN1ASCN5ASCN8APIK3CD | |
| SCHEMBL19968754 | 0.85 | HSD11B1 (0.38) | HSD11B1L3MBTL1SLC40A1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109641873-B | N- (pyridin-2-yl) pyridine-sulfonamide derivatives and their use for the treatment of disease | 诺华股份有限公司 | 2022-03-18 | — | — | CN | disclosed |