Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29469810 | 0.90 | MAPT (0.34) | ADRA1AADRA1BDRD2ADRA1DGAA | |
| SCHEMBL24334009 | 0.90 | MAPT (0.34) | ADRA1AADRA1BDRD2ADRA1DGAA | |
| SCHEMBL24334437 | 0.90 | KMT2A (0.38) | ADRA1AADRA1BDRD2ADRA1DGAA | |
| SCHEMBL24334436 | 0.84 | ADRA1A (0.35) | ADRA1AADRA1BDRD2ADRA1DKAT6A | |
| SCHEMBL24333606 | 0.84 | CA12 (0.31) | MEN1KMT2A | |
| SCHEMBL29469655 | 0.84 | CA12 (0.31) | MEN1KMT2A | |
| SCHEMBL24334327 | 0.82 | KEAP1 (0.38) | GAAMEN1ALDH1A1KMT2A | |
| SCHEMBL24333646 | 0.82 | SLC6A9 (0.36) | GAAMEN1ALDH1A1MAPTMAPK1 | |
| SCHEMBL22588110 | 0.81 | GAA (0.38) | GAAKAT6AMEN1ALDH1A1MAPT | |
| SCHEMBL31525463 | 0.80 | KAT6A (0.41) | DRD2GAAKAT6AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | claimed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | claimed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |