Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24334009 | 1.00 | MAPT (0.34) | MAPTTP53DRD2ADRA1DADRA1A | |
| SCHEMBL29469665 | 0.90 | ADRA1A (0.35) | MAPTDRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL29469724 | 0.90 | MAPT (0.39) | MAPTTP53DRD2ADRA1DADRA1A | |
| SCHEMBL24333981 | 0.90 | MAPT (0.39) | MAPTTP53DRD2ADRA1DADRA1A | |
| SCHEMBL24334327 | 0.86 | KEAP1 (0.38) | LMNAKMT2AGAAMEN1POLB | |
| SCHEMBL24333724 | 0.83 | MAPT (0.37) | MAPTTP53LMNAKMT2AGAA | |
| SCHEMBL29469654 | 0.83 | MAPT (0.37) | MAPTTP53LMNAKMT2AGAA | |
| SCHEMBL24334309 | 0.82 | ALDH1A1 (0.41) | MAPTLMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL24333697 | 0.81 | ALDH1A1 (0.41) | MAPTLMNAKMT2AMEN1KDM4E | |
| SCHEMBL24333713 | 0.81 | MEN1 (0.37) | MAPTTP53DRD2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |