Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 8/20 | 0.55 |
| ▸ | CA1 | P00915 | 5/20 | 0.55 |
| ▸ | CA9 | Q16790 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14919732 | 0.89 | LDHA (0.56) | CDK2CA2CA1CA9CA12 | |
| SCHEMBL9138970 | 0.82 | CDK2 (0.78) | CDK2CA2CA1CA9CA12 | |
| SCHEMBL3966892 | 0.81 | EDNRA (0.49) | CA2CA1CA9CA12EDNRA | |
| SCHEMBL5239888 | 0.81 | TTR (0.55) | EDNRAHTR6ALDH1A1MAPK1 | |
| SCHEMBL29581383 | 0.80 | HTR6 (0.60) | CA2CA1CA9CA12HTR6 | |
| SCHEMBL529620 | 0.80 | HTR6 (0.60) | CA2CA1CA9CA12HTR6 | |
| SCHEMBL31399698 | 0.80 | EDNRA (0.48) | CA2CA1CA9CA12EDNRA | |
| SCHEMBL1523031 | 0.79 | CA2 (0.50) | CA2CA1CA9CA12HTR6 | |
| SCHEMBL11153056 | 0.79 | CA2 (0.50) | CA2CA1CA9CA12HTR6 | |
| SCHEMBL791503 | 0.79 | CA2 (0.50) | CA2CA1CA9CA12HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |