Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 4/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333991 | 1.00 | KMT2A (0.33) | KMT2ARAB9ANPC1ALDH1A1SCN10A | |
| SCHEMBL29469702 | 0.88 | DRD2 (0.35) | KMT2AALDH1A1GAARXFP1PDE4B | |
| SCHEMBL29469656 | 0.87 | S1PR3 (0.33) | KMT2ARAB9ANPC1MEN1TDP1 | |
| SCHEMBL24333957 | 0.87 | S1PR3 (0.33) | KMT2ARAB9ANPC1MEN1TDP1 | |
| SCHEMBL24334427 | 0.85 | PDE4B (0.32) | KMT2ARAB9ANPC1ALDH1A1SCN10A | |
| SCHEMBL24333372 | 0.85 | DCTPP1 (0.37) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL29469870 | 0.85 | DCTPP1 (0.37) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL29469683 | 0.82 | MAPT (0.32) | KMT2ARAB9ANPC1COMTNAMPT | |
| SCHEMBL24333797 | 0.80 | GFER (0.37) | KMT2ARAB9ANPC1ALDH1A1GAA | |
| SCHEMBL29469855 | 0.80 | GFER (0.37) | KMT2ARAB9ANPC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |