Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22587940 | 0.89 | CA1 (0.50) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL741127 | 0.84 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL22588435 | 0.82 | ADRA1D (0.48) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL31411917 | 0.82 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2TSHRCA12CA1 | |
| SCHEMBL10642055 | 0.82 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2TSHRCA12CA1 | |
| SCHEMBL22588505 | 0.81 | ADRA1D (0.52) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL22588071 | 0.81 | RORC (0.46) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL29588239 | 0.81 | ADRA1D (0.52) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL29587949 | 0.81 | RORC (0.46) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL | |
| SCHEMBL29469925 | 0.79 | MEN1 (0.58) | ALDH1A1SMN1; SMN2TSHRKMT2AALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| EP-4229048-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |