Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588505 | 1.00 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BP2RX4CA1 | |
| SCHEMBL24313621 | 0.86 | GLRA1 (0.44) | ADRA1DADRA1AADRA1BALDH1A1SMN1; SMN2 | |
| SCHEMBL29469893 | 0.81 | ALDH1A1 (0.59) | ADRA1DADRA1AADRA1BCA1CA2 | |
| SCHEMBL29588816 | 0.80 | MRGPRX4 (0.50) | ADRA1DADRA1AADRA1BP2RX4CA1 | |
| SCHEMBL22587775 | 0.80 | MRGPRX4 (0.50) | ADRA1DADRA1AADRA1BP2RX4CA1 | |
| SCHEMBL682767 | 0.79 | MAPT (0.49) | ALDH1A1SMN1; SMN2HPGDGLRA1KMT2A | |
| SCHEMBL14200026 | 0.79 | MAPT (0.45) | ALDH1A1SMN1; SMN2GLRA1GAA | |
| SCHEMBL1013565 | 0.78 | CA1 (0.56) | ADRA1DADRA1AADRA1BP2RX4CA1 | |
| SCHEMBL11879060 | 0.77 | P2RX4 (0.55) | ADRA1DADRA1AADRA1BP2RX4ALDH1A1 | |
| SCHEMBL12889910 | 0.77 | GLRA1 (0.50) | ADRA1DADRA1AADRA1BALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4229045-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | The Broad Institute Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |