Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 6/20 | 0.49 |
| ▸ | RORC | P51449 | 4/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867994 | 1.00 | MGLL (0.49) | MGLLRORCGPR119NAMPTSCD5 | |
| SCHEMBL23868059 | 1.00 | MGLL (0.49) | MGLLRORCGPR119NAMPTSCD5 | |
| SCHEMBL23867975 | 1.00 | MGLL (0.49) | MGLLRORCGPR119NAMPTSCD5 | |
| SCHEMBL18368154 | 0.90 | RORC (0.50) | MGLLRORCGPR119NAMPTSCD5 | |
| SCHEMBL23868052 | 0.86 | MGLL (0.54) | MGLLRORCGPR119 | |
| SCHEMBL29469953 | 0.86 | MGLL (0.54) | MGLLRORCGPR119 | |
| SCHEMBL23867931 | 0.86 | MGLL (0.54) | MGLLRORCGPR119 | |
| SCHEMBL23867905 | 0.86 | MGLL (0.54) | MGLLRORCGPR119 | |
| SCHEMBL28916598 | 0.85 | SCD5 (0.53) | MGLLRORCGPR119NAMPTSCD5 | |
| SCHEMBL25411500 | 0.84 | MGLL (0.58) | MGLLRORCGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239776-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2024-07-18 | — | — | US | disclosed |
| US-11897872-B2 | Azaspirocycles as monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2024-02-13 | — | — | US | disclosed |
| US-20230227438-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-20 | — | — | US | disclosed |
| US-11505546-B2 | Azaspirocycles as monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2022-11-22 | — | — | US | disclosed |
| US-20220081428-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239776-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPL, LPAR1 | MGLL 1/4885RORC 974/4885GPR119 254/4885 |
| US-11897872-B2 | Azaspirocycles as monoacylglycerol lipase modulators | MGLL, LPAR1, LPL | MGLL 1/4885RORC 1079/4885GPR119 273/4885 |
| US-20230227438-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPAR1, LPL | MGLL 1/4885RORC 1079/4885GPR119 273/4885 |
| US-20220081428-A1 | AZASPIROCYCLES AS MONOACYLGLYCEROL LIPASE MODULATORS | MGLL, LPAR1, LPL | MGLL 1/4885RORC 1079/4885GPR119 273/4885 |
| US-11505546-B2 | Azaspirocycles as monoacylglycerol lipase modulators | MGLL, LPAR1, LPL | MGLL 1/4885RORC 1079/4885GPR119 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.