Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 5/20 | 0.51 |
| ▸ | DDO | Q99489 | 4/20 | 0.51 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26551030 | 1.00 | BRD4 (0.53) | BRD4DAODDOATAD2CYP1A2 | |
| SCHEMBL30667289 | 0.83 | DAO (0.71) | BRD4DAODDOATAD2CYP1A2 | |
| SCHEMBL16627652 | 0.83 | KDM4E (0.45) | DAODDOCYP1A2TNKS2HRH4 | |
| SCHEMBL20247282 | 0.83 | DAO (0.71) | BRD4DAODDOATAD2CYP1A2 | |
| SCHEMBL30480858 | 0.79 | DAO (0.54) | DAODDOCYP1A2TNKS2HRH4 | |
| SCHEMBL20940200 | 0.79 | DAO (0.65) | BRD4DAODDOATAD2CYP1A2 | |
| SCHEMBL12970533 | 0.79 | DAO (0.65) | BRD4DAODDOATAD2CYP1A2 | |
| SCHEMBL15690473 | 0.79 | DAO (0.65) | DAODDOCYP1A2TNKS2HRH4 | |
| SCHEMBL15690324 | 0.78 | GRIN2D (0.51) | DAODDOCYP1A2HRH4FLT3 | |
| SCHEMBL31098173 | 0.77 | GAA (0.50) | CYP1A2TNKS2CYP2C19HRH4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4210683-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | Aurigene Oncology Limited (IN) | 2023-07-19 | — | — | EP | disclosed |
| CN-116368128-A | Heterocyclic compounds as CBP/EP300 bromodomain inhibitors | 奥瑞基尼肿瘤有限公司 | 2023-06-30 | — | — | CN | disclosed |
| WO-2022053967-A1 | HETEROCYCLIC COMPOUNDS AS CBP/EP300 BROMODOMAIN INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-03-17 | — | — | WO | disclosed |