Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539849 | 1.00 | ALDH1A1 (0.40) | ALDH1A1ACLYMAPTCFTRNPC1 | |
| SCHEMBL25485799 | 0.85 | ALDH1A1 (0.42) | ALDH1A1ACLYMAPTNPC1RAB9A | |
| SCHEMBL29654471 | 0.84 | ABL1 (0.44) | ALDH1A1MAPTCFTRNPC1RAB9A | |
| SCHEMBL24524870 | 0.84 | ABL1 (0.44) | ALDH1A1MAPTCFTRNPC1RAB9A | |
| SCHEMBL29476351 | 0.84 | ALDH1A1 (0.41) | ALDH1A1ACLYMAPTCFTRNPC1 | |
| SCHEMBL23540576 | 0.84 | ALDH1A1 (0.41) | ALDH1A1ACLYMAPTCFTRNPC1 | |
| SCHEMBL29476287 | 0.83 | ALPL (0.41) | ALDH1A1MAPTCFTRNPC1RAB9A | |
| SCHEMBL23539711 | 0.83 | ALPL (0.41) | ALDH1A1MAPTCFTRNPC1RAB9A | |
| SCHEMBL23540410 | 0.82 | CFTR (0.52) | ALDH1A1MAPTCFTRALPLKDM4E | |
| SCHEMBL29476232 | 0.82 | CFTR (0.52) | ALDH1A1MAPTCFTRALPLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4217071-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | Erasca, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022133345-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022066805-A1 | TRICYCLIC PYRIDONES AND PYRIMIDONES | ERASCA, INC. (US) | 2022-03-31 | — | — | WO | disclosed |