Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.61 |
| ▸ | CES1 | P23141 | 2/20 | 0.61 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ERN1 | O75460 | 2/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255000 | 1.00 | CES2 (0.61) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL12469445 | 0.89 | ERN1 (0.59) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL7406706 | 0.85 | MEN1 (0.55) | ERN1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30424341 | 0.85 | PARP1 (0.58) | CES2CES1PARP1OPRM1OPRL1 | |
| Hydrochloric Acid SCHEMBL25222262 | 0.83 | PARP1 (0.56) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL13412201 | 0.82 | CES2 (0.53) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL305837 | 0.82 | CES2 (0.53) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL29729945 | 0.82 | CES2 (0.53) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL7223254 | 0.82 | GRM5 (0.53) | CES2CES1PARP1OPRM1OPRL1 | |
| SCHEMBL12706704 | 0.80 | TSHR (0.54) | CES2CES1PARP1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705292-A1 | CBL-B INHIBITORS AND METHODS OF USE THEREOF | Arcus Biosciences, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024233360-A1 | CBL-B INHIBITORS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2024-11-14 | — | — | WO | disclosed |