Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255000 | 0.89 | CES2 (0.61) | ERN1FYNCES2CES1PARP1 | |
| SCHEMBL29482201 | 0.89 | CES2 (0.61) | ERN1FYNCES2CES1PARP1 | |
| SCHEMBL14784157 | 0.84 | TRPM8 (0.56) | ERN1CES2CES1RELAOPRM1 | |
| SCHEMBL30283775 | 0.84 | ERN1 (0.60) | ERN1PDK2CYP3A4MAP4K1KCNA5 | |
| SCHEMBL1135975 | 0.84 | ERN1 (0.60) | ERN1PDK2CYP3A4MAP4K1KCNA5 | |
| Hydrochloric Acid SCHEMBL28646857 | 0.82 | ERN1 (0.59) | ERN1PDK2CYP3A4MAP4K1KCNA5 | |
| SCHEMBL17795214 | 0.79 | ERN1 (0.60) | ERN1PDK2CYP3A4MAP4K1 | |
| SCHEMBL12472078 | 0.79 | ERN1 (0.56) | ERN1PDK2CYP3A4MAP4K1PARP1 | |
| SCHEMBL18311613 | 0.79 | ERN1 (0.64) | ERN1PDK2FYN | |
| SCHEMBL7406706 | 0.79 | MEN1 (0.55) | ERN1PDK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765667-B2 | HCV protease inhibitors | EISSENSTAT MICHAEL (US) | 2014-07-01 | — | — | US | disclosed |
| US-20110182854-A1 | HCV PROTEASE INHIBITORS | SEQUOIA PHARMACEUTICALS, INC. (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182854-A1 | HCV PROTEASE INHIBITORS | SERPINB1, CTSC, HPN | ERN1 419/4885PDK2 3658/4885FYN 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.