SCHEMBL29488679

SCHEMBL29488679

O=C(O)c1ccc2[nH]c(C(F)F)nc2c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
POLB P06746 1/20 0.51
SMN1; SMN2 Q16637 4/20 0.46
TDP1 Q9NUW8 2/20 0.45
HSP90AA1 P07900 1/20 0.45
ESR2 Q92731 1/20 0.45
MLKL Q8NB16 3/20 0.45
NPC1 O15118 4/20 0.43
RAB9A P51151 4/20 0.43
NR4A2 P43354 1/20 0.43
SIRT2 Q8IXJ6 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KDM4E B2RXH2 4/20 0.40
HPGD P15428 3/20 0.40
APEX1 P27695 1/20 0.40
AURKA O14965 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
RECQL P46063 1/20 0.40
THRB P10828 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12895233 0.84 MLKL (0.54) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL31695250 0.83 CYP1A2 (0.51) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL29488677 0.82 ALDH1A1 (0.50) ALDH1A1POLBSMN1; SMN2NPC1RAB9A
SCHEMBL19970842 0.81 MLKL (0.50) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL22371408 0.79 NPC1 (0.44) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL828113 0.78 KDM4E (0.56) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL10360138 0.78 PRKAG1 (0.49) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL7404851 0.76 MLKL (0.45) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL766092 0.76 TDP1 (0.49) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2
SCHEMBL9305228 0.76 TDP1 (0.49) ALDH1A1SMN1; SMN2TDP1HSP90AA1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114230523-A Benzimidazole derivatives as modulators of ROR-gamma 生命医药有限责任公司 2022-03-25 CN disclosed