Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.48 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24369575 | 1.00 | CA2 (0.48) | CA2CA1CYSLTR2CYSLTR1PTPN1 | |
| SCHEMBL25099306 | 0.81 | HASPIN (0.43) | CA2CA1MAPK1SMN1; SMN2 | |
| SCHEMBL24369658 | 0.80 | PRKCI (0.32) | — | |
| SCHEMBL29488816 | 0.80 | PRKCI (0.32) | — | |
| SCHEMBL24369142 | 0.76 | PRMT6 (0.46) | PTGS1PTGS2 | |
| SCHEMBL29489092 | 0.74 | PTPN1 (0.45) | CA2CA1PTPN1SLC22A12PTPN11 | |
| SCHEMBL24369576 | 0.74 | PTPN1 (0.45) | CA2CA1PTPN1SLC22A12PTPN11 | |
| SCHEMBL5467486 | 0.72 | PTPN1 (0.58) | CA2CA1PTPN1PTPN11MAPK1 | |
| SCHEMBL11615543 | 0.71 | PRKCI (0.38) | — | |
| SCHEMBL3788262 | 0.69 | CA2 (0.62) | CA2CA1PTPN1PTPN11MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232425-A1 | CTPS1 INHIBITORS AND USES THEREOF | Nimbus Clotho, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087634-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS CLOTHO, INC. (US) | 2022-04-28 | — | — | WO | disclosed |