Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.41 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015740 | 0.82 | SREBF2 (0.57) | HASPINCYP1A2CYP3A4ALDH1A1ALOX15 | |
| SCHEMBL29489035 | 0.81 | CA2 (0.48) | MAPK1SMN1; SMN2CA1CA2 | |
| SCHEMBL24369575 | 0.81 | CA2 (0.48) | MAPK1SMN1; SMN2CA1CA2 | |
| SCHEMBL20472857 | 0.80 | PGR (0.52) | ALDH1A1IKBKBCHUKMAPK1LMNA | |
| SCHEMBL24369658 | 0.80 | PRKCI (0.32) | ADRA2CADRA1AADRA1BCYP3A4IKBKB | |
| SCHEMBL29488816 | 0.80 | PRKCI (0.32) | ADRA2CADRA1AADRA1BCYP3A4IKBKB | |
| SCHEMBL24369142 | 0.78 | PRMT6 (0.46) | TDP1KIT | |
| SCHEMBL11615543 | 0.77 | PRKCI (0.38) | ADRA1AADRA1BCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL24003748 | 0.75 | IKBKB (0.49) | CYP1A2CYP3A4ALDH1A1ALOX15IKBKB | |
| SCHEMBL22613423 | 0.74 | SLC22A12 (0.46) | CYP1A2CYP3A4ALDH1A1ALOX15IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230077316-A1 | CTPS1 INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230077316-A1 | CTPS1 INHIBITORS AND USES THEREOF | CTPS1, CTPS2, ECHS1 | HASPIN 1848/4885ADRA2C 4322/4885ADRA1A 4092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.