Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.73 |
| ▸ | APP | P05067 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.62 |
| ▸ | MMP1 | P03956 | 4/20 | 0.62 |
| ▸ | MMP2 | P08253 | 4/20 | 0.62 |
| ▸ | MMP9 | P14780 | 4/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.62 |
| ▸ | TTR | P02766 | 3/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8392957 | 1.00 | IAPP (0.74) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL8392954 | 1.00 | IAPP (0.74) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL14964001 | 0.96 | ALOX5 (0.67) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL29689081 | 0.96 | ALOX5 (0.67) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL4545217 | 0.90 | ALOX5 (0.67) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL30449722 | 0.90 | ALOX5 (0.67) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL1976133 | 0.89 | IAPP (0.66) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL1976131 | 0.89 | IAPP (0.66) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL9694301 | 0.87 | ALOX5 (0.67) | IAPPALOX5APPHSD17B10MMP1 | |
| SCHEMBL29489701 | 0.86 | ALOX5 (0.65) | IAPPALOX5MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240277714-A1 | USE OF SOS1 INHIBITORS WITH RAS INHIBITORS TO TREAT CANCERS | Revolution Medicines, Inc. | 2024-08-22 | — | — | US | disclosed |
| US-20240108630-A1 | METHODS FOR INHIBITING RAS | Revolution Medicines, Inc. | 2024-04-04 | — | — | US | disclosed |
| CN-114921892-B | Powder-coated fabric and preparation method thereof | 无锡市亿润纺织有限公司 | 2024-03-26 | — | — | CN | disclosed |
| US-20220235134-A1 | ANTI-B7-H3 ANTIBODIES | SINGLE CELL TECHNOLOGY, INC. (US) | 2022-07-28 | — | — | US | disclosed |
| EP-3976660-A1 | ANTI-B7-H3 ANTIBODIES | Single Cell Technology, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240277714-A1 | USE OF SOS1 INHIBITORS WITH RAS INHIBITORS TO TREAT CANCERS | SOS1, HRAS, KRAS | IAPP 2592/4885ALOX5 4441/4885APP 3618/4885 |
| US-20240108630-A1 | METHODS FOR INHIBITING RAS | KRAS, HRAS, NRAS | IAPP 3776/4885ALOX5 4608/4885APP 4353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.