Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 6/20 | 0.53 |
| ▸ | FEN1 | P39748 | 6/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948017 | 0.89 | ALOX5AP (0.54) | ALOX5APFEN1FFAR1FFAR4TRPA1 | |
| SCHEMBL23347204 | 0.82 | ALOX5AP (0.56) | ALOX5APFEN1FFAR1FFAR4TRPA1 | |
| SCHEMBL15060621 | 0.78 | ALOX5AP (0.46) | ALOX5APFEN1TAAR1LTB4R2 | |
| SCHEMBL2943305 | 0.76 | FFAR1 (0.45) | ALOX5APFEN1FFAR1FFAR4LTB4R2 | |
| SCHEMBL9287992 | 0.76 | ALOX5AP (0.50) | ALOX5APFEN1FFAR1FFAR4TRPA1 | |
| SCHEMBL2949319 | 0.76 | ALOX5AP (0.54) | ALOX5APFEN1TRPA1PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL2943097 | 0.76 | FFAR1 (0.44) | ALOX5APFEN1FFAR1FFAR4LTB4R2 | |
| SCHEMBL2950123 | 0.75 | ALOX5AP (0.50) | ALOX5APFEN1FFAR1FFAR4TRPA1 | |
| SCHEMBL2943307 | 0.75 | FFAR1 (0.45) | ALOX5APFEN1FFAR1FFAR4BDKRB1 | |
| SCHEMBL9289358 | 0.74 | PTGS2 (0.57) | ALOX5APFEN1TRPA1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |