Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | ADH5 | P11766 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26865466 | 1.00 | MAPT (0.61) | MAPTSIRT6HTTCYP11B1CYP11B2 | |
| SCHEMBL26614095 | 0.90 | MAPT (0.61) | MAPTSIRT6HTTCYP11B1CYP11B2 | |
| SCHEMBL7470078 | 0.84 | MAPT (0.46) | MAPTHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL28722388 | 0.83 | MAPT (0.59) | MAPTSIRT6HTTMAPK8MAPK10 | |
| SCHEMBL7827654 | 0.83 | SIRT6 (0.63) | MAPTSIRT6TDP1LMNAKDM4E | |
| SCHEMBL22028672 | 0.82 | HTT (0.62) | MAPTHTTCYP3A4BAZ2BLMNA | |
| SCHEMBL1308214 | 0.80 | TUBB4A (0.52) | MAPT | |
| SCHEMBL30684529 | 0.80 | ALDH1A1 (0.56) | MAPTSIRT6HTTCYP11B1CYP11B2 | |
| SCHEMBL29495196 | 0.80 | HTT (0.62) | MAPTHTTCYP11B1CYP11B2CYP3A4 | |
| SCHEMBL27480025 | 0.80 | HTT (0.62) | MAPTHTTCYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119487031-A | Tryptanthrin derivatives and uses thereof | 威森特生物公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-119431323-A | Heterobicyclic amides as CD38 inhibitors | 贝林格尔·英格海姆国际有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-114423753-B | Heterobicyclic amides as CD38 inhibitors | 里邦医疗公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-114423753-A | Heterobicyclic amides as CD38 inhibitors | 里邦医疗公司 | 2022-04-29 | — | — | CN | disclosed |