Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22969621 | 1.00 | SHMT2 (0.44) | SHMT2GAACCNCCDK8MTOR | |
| SCHEMBL29495961 | 0.97 | SHMT2 (0.42) | SHMT2GAACCNCCDK8MTOR | |
| SCHEMBL22969277 | 0.97 | SHMT2 (0.42) | SHMT2GAACCNCCDK8MTOR | |
| SCHEMBL22969291 | 0.90 | MAP4K4 (0.39) | SHMT2MTORPIK3CAMCHR1 | |
| SCHEMBL29495699 | 0.90 | MAP4K4 (0.39) | SHMT2MTORPIK3CAMCHR1 | |
| SCHEMBL22969615 | 0.82 | GAA (0.52) | SHMT2GAACCNCCDK8MTOR | |
| SCHEMBL29495731 | 0.82 | GAA (0.52) | SHMT2GAACCNCCDK8MTOR | |
| SCHEMBL22969281 | 0.82 | REN (0.32) | MTORPIK3CAPIK3CGPIK3CB | |
| SCHEMBL29495870 | 0.82 | REN (0.32) | MTORPIK3CAPIK3CGPIK3CB | |
| SCHEMBL22969511 | 0.80 | GAA (0.49) | SHMT2GAACCNCCDK8MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | claimed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |