Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22969291 | 1.00 | MAP4K4 (0.39) | MAP4K4HTR3ADHFRSHMT2REN | |
| SCHEMBL29495744 | 0.90 | SHMT2 (0.44) | SHMT2MTORMCHR1PIK3CA | |
| SCHEMBL22969621 | 0.90 | SHMT2 (0.44) | SHMT2MTORMCHR1PIK3CA | |
| SCHEMBL22969277 | 0.89 | SHMT2 (0.42) | SHMT2MTORPIK3CA | |
| SCHEMBL29495961 | 0.89 | SHMT2 (0.42) | SHMT2MTORPIK3CA | |
| SCHEMBL22969281 | 0.83 | REN (0.32) | RENMTORPIK3CA | |
| SCHEMBL29495870 | 0.83 | REN (0.32) | RENMTORPIK3CA | |
| SCHEMBL29496188 | 0.83 | MAP4K4 (0.41) | MAP4K4HTR3ADHFRSHMT2MAOB | |
| SCHEMBL22969410 | 0.80 | REN (0.43) | DHFRRENMTORMCHR1PARP1 | |
| SCHEMBL29495925 | 0.80 | REN (0.43) | DHFRRENMTORMCHR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | claimed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |