Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 4/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22969281 | 1.00 | REN (0.32) | RENMAP3K12MTORPIK3CAPIK3R1 | |
| SCHEMBL29496133 | 0.85 | MAP3K12 (0.31) | MAP3K12MTORPIM1 | |
| SCHEMBL29495699 | 0.83 | MAP4K4 (0.39) | RENMTORPIK3CA | |
| SCHEMBL22969291 | 0.83 | MAP4K4 (0.39) | RENMTORPIK3CA | |
| SCHEMBL22969621 | 0.82 | SHMT2 (0.44) | MTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29495744 | 0.82 | SHMT2 (0.44) | MTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22969277 | 0.80 | SHMT2 (0.42) | MTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL29495961 | 0.80 | SHMT2 (0.42) | MTORPIK3CAPIK3CBPIK3CG | |
| SCHEMBL22969410 | 0.75 | REN (0.43) | RENMTOR | |
| SCHEMBL29495925 | 0.75 | REN (0.43) | RENMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | claimed |
| EP-4010328-A1 | 5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS | Domain Therapeutics (FR) | 2022-06-15 | — | — | EP | disclosed |
| CN-114269730-A | 5-heteroaryl-pyridin-2-amine compounds as neuropeptide FF receptor antagonists | 多曼治疗学公司 | 2022-04-01 | — | — | CN | disclosed |