Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DTYMK | P23919 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184141 | 0.81 | BCHE (0.47) | GPR119MEN1KMT2ABCHECKS1B | |
| SCHEMBL3697154 | 0.78 | PARP1 (0.47) | POLBALOX15HTTMAPTKDM4E | |
| SCHEMBL22158726 | 0.78 | ALDH1A1 (0.41) | POLBALOX15HTTMAPTMEN1 | |
| SCHEMBL27700993 | 0.77 | MAP4K4 (0.36) | GPR119MAPTCKS1BSKP1SKP2 | |
| SCHEMBL28310442 | 0.76 | ALDH1A1 (0.42) | POLBALOX15HTTMAPTKDM4E | |
| SCHEMBL21598531 | 0.73 | ABL1 (0.47) | POLBGPR119 | |
| SCHEMBL29930920 | 0.73 | GPR119 (0.40) | GPR119GRM1 | |
| Quinoline SCHEMBL27627058 | 0.73 | ALDH1A1 (0.53) | POLBALOX15HTTMAPTKDM4E | |
| Formic Acid SCHEMBL29496205 | 0.73 | ALOX15 (0.37) | POLBALOX15HTTMAPTKDM4E | |
| SCHEMBL7684315 | 0.72 | ALOX15 (0.46) | POLBALOX15HTTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022194122-A1 | NITROGEN-CONTAINING HETEROCYCLIC POLYCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2022-09-22 | — | — | WO | disclosed |
| CN-109641898-B | 5, 7-dihydro-pyrrolo-pyridine derivatives for the treatment of neurological and neurodegenerative diseases | 辉瑞公司 | 2022-04-08 | — | — | CN | disclosed |