Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829429 | 0.86 | CYP3A4 (0.41) | POLBCXCR2HSD11B1CXCR1CA1 | |
| SCHEMBL2380488 | 0.85 | HSD11B1 (0.44) | POLBCXCR2HSD11B1CXCR1CA1 | |
| SCHEMBL10073218 | 0.82 | CYP3A4 (0.49) | POLBCXCR2HSD11B1CXCR1CA1 | |
| SCHEMBL3765038 | 0.80 | CYP2C9 (0.37) | POLBCXCR2HSD11B1CXCR1CA1 | |
| SCHEMBL10073222 | 0.78 | CXCR2 (0.40) | CXCR2HSD11B1CXCR1CA1CA2 | |
| SCHEMBL28162652 | 0.77 | CXCR2 (0.36) | POLBCXCR2HSD11B1CXCR1CYP3A4 | |
| SCHEMBL3203223 | 0.75 | TSHR (0.36) | CXCR2HSD11B1CXCR1CA1CA2 | |
| SCHEMBL1505411 | 0.75 | ALDH1A1 (0.39) | CXCR2HSD11B1CXCR1CA1CA2 | |
| SCHEMBL1252245 | 0.74 | CXCR2 (0.34) | CXCR2HSD11B1CXCR1CA1CA2 | |
| SCHEMBL926505 | 0.73 | CA2 (0.41) | CXCR2HSD11B1CXCR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250042870-A1 | DP ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2025-02-06 | — | — | US | disclosed |
| EP-3854781-B1 | DP ANTAGONISTS | ONO PHARMACEUTICAL CO (JP) | 2024-05-22 | — | — | EP | disclosed |
| US-20220204468-A1 | DP ANTAGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-06-30 | — | — | US | disclosed |
| US-11319296-B2 | DP antagonist | ONO PHARMACEUTICAL CO., LTD. (JP) | 2022-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204468-A1 | DP ANTAGONIST | OPRL1, CNR1, NPSR1 | POLB 4038/4885CXCR2 1315/4885HSD11B1 2075/4885 |
| US-11319296-B2 | DP antagonist | OPRL1, CNR1, NPSR1 | POLB 4038/4885CXCR2 1315/4885HSD11B1 2075/4885 |
| US-20250042870-A1 | DP ANTAGONIST | OPRL1, CNR1, NPSR1 | POLB 4038/4885CXCR2 1315/4885HSD11B1 2075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.