Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6564952 | 0.87 | TPMT (0.39) | TSHRCXCR2HSD11B1SMN1; SMN2CXCR1 | |
| SCHEMBL1187812 | 0.83 | PPARA (0.46) | TSHRCXCR2ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5561363 | 0.79 | FFAR4 (0.37) | TSHRCXCR2HSD11B1CXCR1KMT2A | |
| Iodide SCHEMBL20377402 | 0.78 | FFAR4 (0.36) | TSHRCXCR2HSD11B1CXCR1KMT2A | |
| SCHEMBL3841263 | 0.76 | HSD11B1 (0.31) | CXCR2HSD11B1CXCR1CA1CA2 | |
| SCHEMBL4814757 | 0.76 | MEN1 (0.36) | CXCR2HSD11B1SMN1; SMN2CXCR1ALDH1A1 | |
| SCHEMBL3207214 | 0.76 | EPHX2 (0.34) | CXCR2HSD11B1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL29499587 | 0.75 | POLB (0.38) | CXCR2HSD11B1CXCR1ALDH1A1KMT2A | |
| SCHEMBL6022698 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1CA1CA2 | |
| SCHEMBL6022694 | 0.75 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858850-B1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-21 | — | — | EP | disclosed |
| EP-1858850-B1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-21 | — | — | EP | disclosed |
| CN-101175725-B | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA NV | 2011-02-02 | — | — | CN | disclosed |
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | CAI CHAOZHONG | 2010-06-17 | — | — | US | disclosed |
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | CAI CHAOZHONG | 2010-06-17 | — | — | US | disclosed |
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | CAI CHAOZHONG | 2010-06-17 | — | — | US | disclosed |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | CAI CHAOZHONG | 2010-02-11 | — | — | US | disclosed |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | CAI CHAOZHONG | 2010-02-11 | — | — | US | disclosed |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | CAI CHAOZHONG | 2010-02-11 | — | — | US | disclosed |
| US-7629488-B2 | 2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid; treatment and prevention of pain and gastrointestinal disorders; cost efficiency, industrial scale production | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7629488-B2 | 2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid; treatment and prevention of pain and gastrointestinal disorders; cost efficiency, industrial scale production | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7629488-B2 | 2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid; treatment and prevention of pain and gastrointestinal disorders; cost efficiency, industrial scale production | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| CN-101175725-A | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-07 | — | — | CN | disclosed |
| CN-101175726-A | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-05-07 | — | — | CN | disclosed |
| EP-1863764-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1858850-A2 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006099060-A2 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006098982-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-21 | — | — | WO | disclosed |
| US-20060211861-A1 | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
| US-20060211863-A1 | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | OPRM1, OPRK1, OPRL1 | TSHR 1255/4885HTT 2747/4885APOBEC3A 4053/4885 |
| US-20060211861-A1 | Process for the preparation of opioid modulators | OPRM1, OPRK1, OPRL1 | TSHR 1255/4885HTT 2747/4885APOBEC3A 4053/4885 |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | OPRM1, OPRL1, OPRK1 | TSHR 890/4885HTT 3787/4885APOBEC3A 3531/4885 |
| US-20060211863-A1 | Process for the preparation of opioid modulators | OPRM1, OPRK1, OPRL1 | TSHR 1255/4885HTT 2747/4885APOBEC3A 4053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.