SCHEMBL29501063

SCHEMBL29501063

COc1ccc2c(c1)C=CCN2Cc1cccc2ccccc12

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FAAH O00519 4/20 0.48
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
NPBWR1 P48145 3/20 0.41
HTR1A P08908 1/20 0.40
SLC6A4 P31645 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39
AKR1B1 P15121 1/20 0.39
HTR2A P28223 1/20 0.38
NQO2 P16083 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29500998 0.82 DAO (0.39) FAAHMEN1KMT2A
SCHEMBL29500974 0.81 DRD2 (0.42) FAAHALDH1A1KMT2A
Hydrochloric Acid SCHEMBL29189720 0.80 DRD2 (0.41) FAAHALDH1A1KMT2A
SCHEMBL30293250 0.77 GSK3A (0.42) KDM4EALDH1A1
SCHEMBL4299024 0.76 KDM4E (0.41) KDM4EALDH1A1MEN1KMT2ATDP1
Iodide SCHEMBL29405935 0.74 KDM4E (0.40) KDM4EALDH1A1MEN1KMT2ATDP1
Iodide SCHEMBL28887683 0.74 KDM4E (0.40) KDM4EALDH1A1MEN1KMT2ATDP1
SCHEMBL28426315 0.72 BRD4 (0.38) KDM4EALDH1A1KMT2AHTR2A
SCHEMBL30783424 0.70 SIGMAR1 (0.48) KDM4EALDH1A1L3MBTL1
Iodide SCHEMBL30293255 0.68 LMNA (0.39) KDM4EALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114380743-B Method for introducing trifluoromethylthio into nitrogen-containing compound 四川大学 2023-08-11 CN disclosed
CN-114380743-A Method for introducing trifluoromethylthio group into nitrogen-containing compound 四川大学 2022-04-22 CN disclosed