Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29501054 | 0.80 | TGFBR1 (0.44) | TGFBR1IRAK4 | |
| SCHEMBL29501050 | 0.79 | TGFBR1 (0.54) | TGFBR1IRAK4 | |
| SCHEMBL25942605 | 0.77 | TGFBR1 (0.55) | TGFBR1ACVR1BIRAK4 | |
| SCHEMBL25334386 | 0.76 | TGFBR1 (0.55) | TGFBR1ACVR1BIRAK4 | |
| SCHEMBL25942816 | 0.75 | TGFBR1 (0.41) | TGFBR1ACVR1BIRAK4 | |
| SCHEMBL25942308 | 0.74 | IRAK4 (0.42) | TGFBR1IRAK4 | |
| SCHEMBL29501081 | 0.72 | IRAK4 (0.39) | TGFBR1ACVR1BIRAK4 | |
| SCHEMBL29425322 | 0.72 | TGFBR1 (0.40) | TGFBR1ACVR1BIRAK4 | |
| SCHEMBL22228602 | 0.69 | TGFBR1 (0.44) | TGFBR1 | |
| SCHEMBL25943074 | 0.67 | POLB (0.39) | TGFBR1ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380818-A | Pyrazolo pyridine compound, and pharmaceutical composition, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-04-22 | — | — | CN | disclosed |