Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.30 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976627 | 0.84 | TSHR (0.35) | HPGDIDO1 | |
| SCHEMBL18421429 | 0.84 | TSHR (0.35) | GAAMCL1IDO1 | |
| SCHEMBL11880006 | 0.76 | MAPT (0.41) | MAPTKMT2AGAANPC1HPGD | |
| SCHEMBL27931109 | 0.75 | ERN1 (0.31) | MAPTKMT2A | |
| SCHEMBL4115494 | 0.73 | ALDH1A1 (0.41) | MAPTKMT2AGAAMCL1NPC1 | |
| SCHEMBL15218429 | 0.72 | CCR2 (0.38) | MAPTKMT2AHPGDSMN1; SMN2 | |
| SCHEMBL1639839 | 0.71 | CA1 (0.50) | MAPTGAAKDM1AKDM1B | |
| SCHEMBL17176604 | 0.70 | GAA (0.55) | MAPTKMT2AGAARAB9ASMN1; SMN2 | |
| SCHEMBL263907 | 0.70 | PDK2 (0.37) | NPC1HPGDRAB9ASMN1; SMN2KDM1A | |
| SCHEMBL22165559 | 0.70 | TSHR (0.35) | MCL1NPC1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396301-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | Jerini AG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010091876-A2 | SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2010-08-19 | — | — | WO | disclosed |