Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20843845 | 1.00 | F11 (0.31) | F11LPLLIPGP2RX7 | |
| SCHEMBL30077920 | 0.79 | JAK2 (0.36) | LPLLIPGP2RX7 | |
| SCHEMBL9941917 | 0.79 | LPL (0.36) | LPLLIPGP2RX7 | |
| SCHEMBL28438600 | 0.78 | UCHL1 (0.32) | — | |
| SCHEMBL27191758 | 0.77 | ESR2 (0.31) | — | |
| SCHEMBL31663361 | 0.77 | ESR2 (0.31) | — | |
| SCHEMBL24667027 | 0.76 | UCHL1 (0.35) | — | |
| SCHEMBL29977339 | 0.76 | UCHL1 (0.35) | — | |
| SCHEMBL20519704 | 0.76 | AAK1 (0.35) | LPLLIPG | |
| SCHEMBL22906863 | 0.75 | LPL (0.36) | F11LPLLIPGP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240363-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098806-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |