Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | HTR2B | P41595 | 7/20 | 0.44 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | HPN | P05981 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3602646 | 0.99 | SIGMAR1 (0.46) | SIGMAR1SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL20942315 | 0.86 | ENPP2 (0.43) | HTR2CHTR2BHTR2AF10HPN | |
| SCHEMBL17062837 | 0.86 | F10 (0.42) | HTR2CHTR2BHTR2AF10HPN | |
| SCHEMBL31495468 | 0.83 | GAA (0.48) | SIGMAR1HTR2CHTR2BHTR2ACHRM3 | |
| SCHEMBL20616290 | 0.83 | F10 (0.40) | HTR2CHTR2BHTR2AF10HPN | |
| SCHEMBL20616288 | 0.83 | F10 (0.40) | HTR2CHTR2BHTR2AF10HPN | |
| Hydrochloric Acid SCHEMBL31570652 | 0.82 | GAA (0.47) | SIGMAR1HTR2CHTR2BHTR2ACHRM3 | |
| Hydrochloric Acid SCHEMBL30713220 | 0.82 | GAA (0.47) | SIGMAR1HTR2CHTR2BHTR2ACHRM3 | |
| Trifluoroacetic Acid SCHEMBL22390477 | 0.80 | ENPP2 (0.39) | HTR2CHTR2BHTR2AF10HPN | |
| Trifluoroacetic Acid SCHEMBL31655669 | 0.80 | F10 (0.39) | HTR2CHTR2BHTR2AF10HPN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349969-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阵列生物制药公司 | 2022-05-10 | — | — | CN | disclosed |