Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20560951 | 1.00 | ALOX15 (0.43) | ALOX15GFERADAM17MEN1KMT2A | |
| SCHEMBL8163306 | 0.85 | GPR3 (0.41) | ALOX15LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25368387 | 0.83 | ALOX15 (0.43) | ALOX15GFERADAM17MEN1KMT2A | |
| SCHEMBL17175976 | 0.79 | THRA (0.40) | MEN1KMT2ALMNASMN1; SMN2HTT | |
| SCHEMBL15016881 | 0.79 | ALOX15 (0.43) | ALOX15GFERADAM17MEN1KMT2A | |
| SCHEMBL30599536 | 0.79 | PKM (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL29888754 | 0.79 | ALOX15 (0.43) | ALOX15GFERADAM17MEN1KMT2A | |
| SCHEMBL1438674 | 0.79 | PKM (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL20562225 | 0.79 | MEN1 (0.43) | ALOX15GFERADAM17MEN1KMT2A | |
| SCHEMBL30571340 | 0.79 | MEN1 (0.43) | ALOX15GFERADAM17MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026096-B | Tetrazole-substituted pyrazolopyrimidine JAK kinase inhibitor and application thereof | 豪夫迈·罗氏有限公司 | 2025-02-07 | — | — | CN | disclosed |
| CN-110650959-B | Therapeutic compounds and compositions and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-04-18 | — | — | CN | disclosed |
| EP-3986900-A1 | TETRAZOLE-SUBSTITUTED PYRAZOLOPYRIMIDINE INHIBITORS OF JAK KINASES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2022-04-27 | — | — | EP | disclosed |