Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 6/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14464189 | 0.81 | ALDH1A1 (0.79) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL854050 | 0.80 | ALDH1A1 (0.71) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL30198175 | 0.80 | ALDH1A1 (0.71) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL10036389 | 0.79 | ALDH1A1 (0.54) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL30345929 | 0.79 | SIRT6 (0.60) | ALDH1A1LMNAKMT2AMAPTPOLB | |
| SCHEMBL29520501 | 0.78 | MAPT (0.51) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL14131744 | 0.77 | ALDH1A1 (0.52) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL14131396 | 0.77 | ALDH1A1 (0.52) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL7818416 | 0.77 | ALDH1A1 (0.58) | ALDH1A1LMNAKMT2AMAPTTHRB | |
| SCHEMBL22175055 | 0.76 | ALDH1A1 (0.57) | ALDH1A1LMNAKMT2AMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |