Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | GFER | P55789 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17265648 | 0.78 | ALDH1A1 (0.77) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL29520409 | 0.78 | ALDH1A1 (0.57) | MAPTALDH1A1LMNAMAPK1SLC6A9 | |
| SCHEMBL29520597 | 0.77 | ALDH1A1 (0.66) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL159044 | 0.77 | ALDH1A1 (0.66) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL29520446 | 0.77 | KDM4E (0.41) | MAPTALDH1A1LMNAKDM4EL3MBTL1 | |
| SCHEMBL26087838 | 0.75 | MAPT (0.55) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL23126590 | 0.74 | MAPT (0.54) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL25091068 | 0.73 | ALDH1A1 (0.49) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL3011234 | 0.72 | ALDH1A1 (0.59) | MAPTALDH1A1GFERLMNAMAPK1 | |
| SCHEMBL880495 | 0.72 | ALDH1A1 (0.59) | MAPTALDH1A1GFERLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |