Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | XDH | P47989 | 1/20 | 0.59 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenine SCHEMBL6162502 | 0.93 | PI4KA (0.51) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL1577866 | 0.87 | LMNA (0.56) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL4201626 | 0.83 | PI4KA (0.55) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL28186581 | 0.83 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL28113157 | 0.83 | PI4KA (0.71) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Glutamine SCHEMBL27878718 | 0.82 | PI4KA (0.56) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Lysine SCHEMBL28077124 | 0.82 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL9663406 | 0.81 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL6162497 | 0.81 | PI4KA (0.46) | PI4KAPI4K2BPI4K2API4KBLMNA | |
| Adenine SCHEMBL385842 | 0.81 | LMNA (0.92) | PI4KAPI4K2BPI4K2API4KBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250146077-A1 | NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF | FOUNDATION MEDICINE, INC. (US) | 2025-05-08 | — | — | US | disclosed |
| US-12116638-B2 | Estrogen receptor mutations and uses thereof | FOUNDATION MEDICINE, INC. (US) | 2024-10-15 | — | — | US | disclosed |
| US-20220251667-A1 | NOVEL ESTROGEN RECEPTOR MUTATIONS AND USES THEREOF | FOUNDATION MEDICINE, INC. (US) | 2022-08-11 | — | — | US | disclosed |
| US-11286532-B2 | Estrogen receptor mutations and uses thereof | FOUNDATION MEDICINE, INC. (US) | 2022-03-29 | — | — | US | disclosed |