Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.31 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272091 | 0.79 | HSP90AA1 (0.40) | HRH4P2RX7HSP90AA1NAMPTKCNH3 | |
| SCHEMBL28596505 | 0.76 | P2RX7 (0.39) | HRH4P2RX7HSP90AA1NAMPTKCNH3 | |
| SCHEMBL1153882 | 0.76 | HSP90AA1 (0.40) | HRH4P2RX7HSP90AA1NAMPTKCNH3 | |
| SCHEMBL1272090 | 0.76 | KCNH3 (0.36) | HRH4P2RX7HSP90AA1NAMPTKCNH3 | |
| SCHEMBL28362861 | 0.75 | SYK (0.34) | HRH4P2RX7HSP90AA1NAMPTKCNH3 | |
| SCHEMBL29525469 | 0.73 | NAMPT (0.43) | NAMPTNPC1 | |
| SCHEMBL9597906 | 0.71 | CXCR4 (0.41) | HRH4P2RX7HSP90AA1KCNH3TSHR | |
| SCHEMBL12088922 | 0.69 | CXCR4 (0.36) | HRH4HSP90AA1KCNH3CXCR4NPC1 | |
| SCHEMBL8717420 | 0.69 | HSP90AA1 (0.44) | P2RX7HSP90AA1NAMPTKCNH3CYP1B1 | |
| SCHEMBL27857050 | 0.68 | CHRNA7 (0.43) | HSP90AA1TSHRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983409-A1 | PYRIDYL OR PYRIMIDYL MTOR KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2022-04-20 | — | — | EP | disclosed |