Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 17/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 13/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | THRA | P10827 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527328 | 0.91 | NPBWR1 (0.39) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526904 | 0.89 | NPBWR1 (0.37) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29527217 | 0.88 | NPBWR1 (0.37) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526860 | 0.86 | NPBWR1 (0.36) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526892 | 0.80 | THRB (0.41) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526929 | 0.79 | NPBWR1 (0.39) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29527467 | 0.77 | NPBWR1 (0.34) | NPBWR1MCHR1ALDH1A1 | |
| SCHEMBL24407929 | 0.76 | THRB (0.55) | THRATHRB | |
| SCHEMBL29527120 | 0.74 | THRB (0.39) | NPBWR1MCHR1THRATHRB | |
| SCHEMBL29527283 | 0.73 | THRB (0.48) | NPBWR1MCHR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | claimed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | claimed |
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |