Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 5/20 | 0.41 |
| ▸ | THRA | P10827 | 4/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 14/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 12/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527283 | 0.83 | THRB (0.48) | THRBTHRANPBWR1MCHR1CYP2C9 | |
| SCHEMBL29527328 | 0.82 | NPBWR1 (0.39) | THRBTHRANPBWR1MCHR1LMNA | |
| SCHEMBL29526904 | 0.81 | NPBWR1 (0.37) | THRBTHRANPBWR1MCHR1LMNA | |
| SCHEMBL30558167 | 0.80 | THRB (0.63) | THRBTHRA | |
| SCHEMBL29527217 | 0.80 | NPBWR1 (0.37) | THRBTHRANPBWR1MCHR1LMNA | |
| SCHEMBL29526658 | 0.80 | NPBWR1 (0.35) | THRBTHRANPBWR1MCHR1LMNA | |
| SCHEMBL29526860 | 0.78 | NPBWR1 (0.36) | THRBTHRANPBWR1MCHR1LMNA | |
| SCHEMBL29527903 | 0.78 | THRB (0.40) | THRBTHRANPBWR1MCHR1CYP2C9 | |
| SCHEMBL29526742 | 0.77 | THRB (0.35) | THRBTHRANPBWR1MCHR1CYP2C9 | |
| SCHEMBL24407921 | 0.75 | THRB (0.65) | THRBTHRACYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | claimed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | claimed |
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |