Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 19/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 15/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527328 | 0.79 | NPBWR1 (0.39) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526658 | 0.79 | NPBWR1 (0.35) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL24408059 | 0.78 | THRB (0.53) | NPBWR1MCHR1 | |
| SCHEMBL29526904 | 0.78 | NPBWR1 (0.37) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29527217 | 0.77 | NPBWR1 (0.37) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29527635 | 0.77 | THRB (0.39) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526743 | 0.75 | THRB (0.40) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29526860 | 0.75 | NPBWR1 (0.36) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 | |
| SCHEMBL29527347 | 0.75 | THRA (0.56) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29526892 | 0.75 | THRB (0.41) | NPBWR1MCHR1NPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |