Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 19/20 | 0.49 |
| ▸ | THRA | P10827 | 16/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29066209 | 1.00 | THRB (0.49) | THRBTHRACYP2C8CYP2C9NPC1 | |
| SCHEMBL24450109 | 0.97 | THRA (0.51) | THRBTHRACYP2C8CYP2C9NPC1 | |
| SCHEMBL24450107 | 0.84 | THRB (0.50) | THRBTHRACYP2C8CYP2C9 | |
| SCHEMBL29066213 | 0.84 | THRB (0.54) | THRBTHRACYP2C8CYP2C9NPC1 | |
| SCHEMBL29526700 | 0.84 | THRB (0.54) | THRBTHRACYP2C8CYP2C9NPC1 | |
| SCHEMBL24450031 | 0.84 | THRB (0.51) | THRBTHRACYP2C8CYP2C9 | |
| SCHEMBL29527043 | 0.83 | THRA (0.52) | THRBTHRACYP2C8CYP2C9NPC1 | |
| SCHEMBL29066258 | 0.83 | THRA (0.52) | THRBTHRACYP2C8CYP2C9NPC1 | |
| SCHEMBL29527177 | 0.83 | THRA (0.64) | THRBTHRACYP2C8CYP2C9 | |
| SCHEMBL29066175 | 0.83 | THRA (0.64) | THRBTHRACYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |