Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 18/20 | 0.52 |
| ▸ | THRB | P10828 | 18/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527043 | 1.00 | THRA (0.52) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL29066213 | 0.87 | THRB (0.54) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL29526700 | 0.87 | THRB (0.54) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL29527177 | 0.86 | THRA (0.64) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29066175 | 0.86 | THRA (0.64) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL24450109 | 0.84 | THRA (0.51) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL29527151 | 0.83 | THRB (0.49) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL29066209 | 0.83 | THRB (0.49) | THRATHRBCYP2C9CYP2C8NPC1 | |
| SCHEMBL29066176 | 0.81 | THRA (0.47) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29527065 | 0.81 | THRA (0.47) | THRATHRBCYP2C9CYP2C8UGT1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |