Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.39 |
| ▸ | THRA | P10827 | 18/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527598 | 0.89 | THRB (0.39) | THRBTHRANPBWR1MCHR1 | |
| SCHEMBL29527567 | 0.82 | THRA (0.39) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527109 | 0.80 | THRA (0.33) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL30083009 | 0.78 | THRB (0.40) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527046 | 0.77 | NPBWR1 (0.34) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL24407897 | 0.75 | THRB (0.69) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL24407975 | 0.72 | THRB (0.70) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527283 | 0.72 | THRB (0.48) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL31258423 | 0.71 | THRB (0.47) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29526895 | 0.71 | THRB (0.43) | THRBTHRACYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |