Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.41 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948828 | 0.91 | RAB9A (0.42) | RAB9ANPC1KMT2AMEN1LMNA | |
| SCHEMBL1704731 | 0.89 | CYP3A4 (0.43) | NAMPTLATS1LATS2ALDH1A1RAB9A | |
| SCHEMBL2945099 | 0.88 | ALDH1A1 (0.42) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL1704061 | 0.87 | LATS1 (0.43) | NAMPTLATS1LATS2ALDH1A1KMT2A | |
| SCHEMBL2944090 | 0.87 | CCNC (0.46) | CCNCCDK8NAMPTALDH1A1RAB9A | |
| SCHEMBL1704446 | 0.87 | MAPK1 (0.44) | NAMPTLATS1LATS2RAB9AKMT2A | |
| SCHEMBL2953212 | 0.87 | LATS1 (0.43) | LATS1LATS2ALDH1A1RAB9ANPC1 | |
| SCHEMBL1705388 | 0.86 | RAB9A (0.43) | LATS1LATS2ALDH1A1RAB9ANPC1 | |
| SCHEMBL2956022 | 0.85 | MEN1 (0.46) | NAMPTLATS1LATS2ALDH1A1RAB9A | |
| SCHEMBL1704411 | 0.84 | MAPT (0.43) | LATS1LATS2ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759350-B2 | Pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-20 | — | — | US | claimed |
| EP-1931642-A2 | NOVEL PYRIMIDINE CARBOXAMIDES | Orchid Research Laboratories Limited (IN) | 2008-06-18 | — | — | EP | claimed |
| US-20070072876-A1 | Novel pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2007-03-29 | — | — | US | claimed |
| WO-2007031829-A2 | NOVEL PYRIMIDINE CARBOXAMIDES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-03-22 | — | — | WO | claimed |
| US-7759350-B2 | Pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-20 | — | — | US | disclosed |
| US-7759350-B2 | Pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-20 | — | — | US | disclosed |
| US-7759350-B2 | Pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2010-07-20 | — | — | US | disclosed |
| EP-1931642-A2 | NOVEL PYRIMIDINE CARBOXAMIDES | Orchid Research Laboratories Limited (IN) | 2008-06-18 | — | — | EP | disclosed |
| US-20070072876-A1 | Novel pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2007-03-29 | — | — | US | disclosed |
| US-20070072876-A1 | Novel pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2007-03-29 | — | — | US | disclosed |
| US-20070072876-A1 | Novel pyrimidine carboxamides | ORCHID RESEARCH LABORATORIES LTD. (IN) | 2007-03-29 | — | — | US | disclosed |
| WO-2007031829-A2 | NOVEL PYRIMIDINE CARBOXAMIDES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-03-22 | — | — | WO | disclosed |
| WO-2007031829-A2 | NOVEL PYRIMIDINE CARBOXAMIDES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072876-A1 | Novel pyrimidine carboxamides | UACA, SI, MYLK2 | CCNC 3445/4885CDK8 243/4885NAMPT 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.