Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.58 |
| ▸ | WNT3A | P56704 | 3/20 | 0.58 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3359574 | 1.00 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3TSHRKIF11 | |
| Hydrochloric Acid SCHEMBL31726879 | 0.98 | CTNNB1 (0.56) | CTNNB1WNT3ASMYD3TSHRKIF11 | |
| SCHEMBL15104920 | 0.89 | TSHR (0.53) | CTNNB1WNT3ASMYD3TSHRKIF11 | |
| SCHEMBL10407674 | 0.85 | CTNNB1 (0.61) | CTNNB1WNT3ASMYD3KIF11MRGPRX4 | |
| SCHEMBL3866171 | 0.83 | CTNNB1 (0.59) | CTNNB1WNT3ASMYD3KIF11MRGPRX4 | |
| SCHEMBL351400 | 0.83 | CTNNB1 (0.64) | CTNNB1WNT3ASMYD3TSHRMRGPRX4 | |
| SCHEMBL29746867 | 0.81 | TSHR (0.53) | CTNNB1WNT3ASMYD3TSHRKIF11 | |
| SCHEMBL1257050 | 0.81 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3KIF11MRGPRX4 | |
| SCHEMBL19160022 | 0.81 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3KIF11MRGPRX4 | |
| SCHEMBL1347343 | 0.81 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3MRGPRX4HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133600-A1 | PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-05-04 | — | — | US | claimed |
| EP-4098258-A1 | PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-12-07 | — | — | EP | claimed |
| US-20220112177-A1 | KETOAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2022-04-14 | — | — | US | claimed |
| US-12636275-B2 | Pharmaceutical use of ketoamide-based compound | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2026-05-26 | — | — | US | disclosed |
| WO-2025235833-A1 | RXFP1 RECEPTOR AGONISTS | ELI LILLY AND COMPANY (US) | 2025-11-13 | — | — | WO | disclosed |
| US-12152017-B2 | Ketoamide compound and preparation method, pharmaceutical composition, and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2024-11-26 | — | — | US | disclosed |
| CN-116730995-B | Hydrazide compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-113015726-B | Ketone amide compound and preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-03-08 | — | — | CN | disclosed |
| WO-2024032715-A1 | HYDRAZIDE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳微芯生物科技股份有限公司 | 2024-02-15 | — | — | WO | disclosed |
| CN-116730995-A | Hydrazide compound, preparation method and application thereof | 深圳微芯生物科技股份有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-113197895-B | Pharmaceutical application of ketoamide compound | 中国科学院上海药物研究所 | 2023-06-20 | — | — | CN | disclosed |
| US-20230133600-A1 | PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2023-05-04 | — | — | US | disclosed |
| EP-4098258-A1 | PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2022-12-07 | — | — | EP | disclosed |
| US-20220112177-A1 | KETOAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | FUDAN UNIVERSITY (CN) | 2022-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220112177-A1 | KETOAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF | ACE, REN, ACE2 | CTNNB1 2071/4885WNT3A 4041/4885SMYD3 2403/4885 |
| US-20230133600-A1 | PHARMACEUTICAL USE OF KETOAMIDE-BASED COMPOUND | CTSL, CTSV, CTSS | CTNNB1 2194/4885WNT3A 4064/4885SMYD3 2813/4885 |
| US-12636275-B2 | Pharmaceutical use of ketoamide-based compound | CTSV, CTSL, CTSS | CTNNB1 2406/4885WNT3A 3863/4885SMYD3 3558/4885 |
| US-12152017-B2 | Ketoamide compound and preparation method, pharmaceutical composition, and use thereof | ACE, REN, ACE2 | CTNNB1 2071/4885WNT3A 4041/4885SMYD3 2403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.